Whub web portal

slide1

Whub portal

Whub is a resource to study functional Trp(W)-containing motifs in animal, plant and viral proteins.

Whub offers:

  • Protein catalog
  • Scanning tools
  • Domain analysis
  • Domain designer
slide2

PWM-based approach

Tryptophan is crucial for the interaction, and the contributions of its two adjacent amino-acid residues are more important than residues at more distant surrounding position.

The implementation of such a model follows the basic idea behind position weight matrix (PWM). In this way, Trp is assumed as a midpoint of the matrix, and likelihoods of all other non-tryptophan amino acid spread along more distant positions in both directions from the central residue.

Whub a portal to study functional W-containing motifs in animal, plant and viral proteins.

Glycine/tryptophane (GW) proteins are strictly required in siRNA- and miRNA-mediated gene silencing in all Eukaryotes. GW protein interacts with its functional partner Argonaute proteins (AGO) via WG/GW motifs and form an effector complexes known as RISC.

Whub offers a suite of tools to study functional W-containing motifs in animal, plant and viral proteins. Read more

Quick launch
Scan sequence
Matrix
5

Relevant papers

Look through W-concerning articles

Filter papers based on function, organism of W motifs..

63
Download Wsearch
v.1.0

News

New AGO-binder: NEF from HIV-1.

Two short GW motifs bind human AGO2. One motif is sufficient for the binding.

Jan 2017
GW Proteins
18
DomainDesigner

AGO-binding candidates

Download ranking proteins in protists, plants, animals, fungi, bacteria and viruses

File Manager
How to cite

If you find our site useful please support our project by citing the following publication

Zielezinski A. & Karlowski WM.
Integrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.
Bioinformatics. Bioinformatics. 2015 31(3):332-9. PubMed

Server stats
0%
CPU
0%
RAM
Updates
  • Portlets are draggable
    1 year ago
  • Added Wsearch-RT
    2 years, 2 months ago
  • Modified filters and minor improvements
    2 years, 9 months ago
  • Game graphics improvement
    2 years, 9 months ago
  • Added heatmap in Wsearch results
    1 year, 10 months ago
  • Added feature: paper-to-protein
    1 year, 10 months ago
  • Added GW protein: HIV-1 Nef
    1 year, 12 months ago
  • Added Papers framework
    3 years, 2 months ago
  • Whub runs on Django engine
    3 years, 3 months ago
  • Added viral matrix
    3 years, 3 months ago
  • Added motif distances
    3 years, 3 months ago
  • Added server usage statistics
    3 years, 3 months ago
  • Heatmap visualization framework
    3 years, 4 months ago
  • Added matrix: plant AGO-binding domain
    3 years, 4 months ago
  • Added Wsearch - chart visualization
    3 years, 4 months ago
  • Added GW protein: NSs
    3 years, 4 months ago
  • Wsearch on-line implementation
    3 years, 4 months ago
  • Whub - initial release
    3 years, 4 months ago