Whub web portal
Whub a portal to study functional W-containing motifs in animal, plant and viral proteins.
Glycine/tryptophane (GW) proteins are strictly required in siRNA- and miRNA-mediated gene silencing in all Eukaryotes. GW protein interacts with its functional partner Argonaute proteins (AGO) via WG/GW motifs and form an effector complexes known as RISC.
Whub offers a suite of tools to study functional W-containing motifs in animal, plant and viral proteins. Read more
Relevant papers
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News
New AGO-binder: NEF from HIV-1.
Two short GW motifs bind human AGO2. One motif is sufficient for the binding.
AGO-binding candidates
Download ranking proteins in protists, plants, animals, fungi, bacteria and viruses
If you find our site useful please support our project by citing the following publication
Zielezinski A. & Karlowski WM.
Integrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.
Bioinformatics. Bioinformatics. 2015 31(3):332-9. PubMed