Whub web portal
Whub is a resource to study functional Trp(W)-containing motifs in animal, plant and viral proteins.
- Protein catalog
- Scanning tools
- Domain analysis
- Domain designer
Tryptophan is crucial for the interaction, and the contributions of its two adjacent amino-acid residues are more important than residues at more distant surrounding position.
The implementation of such a model follows the basic idea behind position weight matrix (PWM). In this way, Trp is assumed as a midpoint of the matrix, and likelihoods of all other non-tryptophan amino acid spread along more distant positions in both directions from the central residue.
Whub a portal to study functional W-containing motifs in animal, plant and viral proteins.
Glycine/tryptophane (GW) proteins are strictly required in siRNA- and miRNA-mediated gene silencing in all Eukaryotes. GW protein interacts with its functional partner Argonaute proteins (AGO) via WG/GW motifs and form an effector complexes known as RISC.
Whub offers a suite of tools to study functional W-containing motifs in animal, plant and viral proteins. Read more
Look through W-concerning articles
Filter papers based on function, organism of W motifs..
New AGO-binder: NEF from HIV-1.
Two short GW motifs bind human AGO2. One motif is sufficient for the binding.
Download ranking proteins in protists, plants, animals, fungi, bacteria and viruses
If you find our site useful please support our project by citing the following publication
Zielezinski A. & Karlowski WM.
Integrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.
Bioinformatics. Bioinformatics. 2015 31(3):332-9. PubMed