Whub web portal


Whub portal

Whub is a resource to study functional Trp(W)-containing motifs in animal, plant and viral proteins.

Whub offers:

  • Protein catalog
  • Scanning tools
  • Domain analysis
  • Domain designer

PWM-based approach

Tryptophan is crucial for the interaction, and the contributions of its two adjacent amino-acid residues are more important than residues at more distant surrounding position.

The implementation of such a model follows the basic idea behind position weight matrix (PWM). In this way, Trp is assumed as a midpoint of the matrix, and likelihoods of all other non-tryptophan amino acid spread along more distant positions in both directions from the central residue.

Whub a portal to study functional W-containing motifs in animal, plant and viral proteins.

Glycine/tryptophane (GW) proteins are strictly required in siRNA- and miRNA-mediated gene silencing in all Eukaryotes. GW protein interacts with its functional partner Argonaute proteins (AGO) via WG/GW motifs and form an effector complexes known as RISC.

Whub offers a suite of tools to study functional W-containing motifs in animal, plant and viral proteins. Read more

Quick launch
Scan sequence

Relevant papers

Look through W-concerning articles

Filter papers based on function, organism of W motifs..

Download Wsearch


New AGO-binder: NEF from HIV-1.

Two short GW motifs bind human AGO2. One motif is sufficient for the binding.

Jan 2017
GW Proteins

AGO-binding candidates

Download ranking proteins in protists, plants, animals, fungi, bacteria and viruses

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How to cite

If you find our site useful please support our project by citing the following publication

Zielezinski A. & Karlowski WM.
Integrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.
Bioinformatics. Bioinformatics. 2015 31(3):332-9. PubMed

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  • Portlets are draggable
    7 years, 5 months ago
  • Added Wsearch-RT
    8 years, 6 months ago
  • Modified filters and minor improvements
    9 years, 1 month ago
  • Game graphics improvement
    9 years, 1 month ago
  • Added heatmap in Wsearch results
    8 years, 2 months ago
  • Added feature: paper-to-protein
    8 years, 3 months ago
  • Added GW protein: HIV-1 Nef
    8 years, 4 months ago
  • Added Papers framework
    9 years, 6 months ago
  • Whub runs on Django engine
    9 years, 7 months ago
  • Added viral matrix
    9 years, 7 months ago
  • Added motif distances
    9 years, 7 months ago
  • Added server usage statistics
    9 years, 8 months ago
  • Heatmap visualization framework
    9 years, 8 months ago
  • Added matrix: plant AGO-binding domain
    9 years, 8 months ago
  • Added Wsearch - chart visualization
    9 years, 8 months ago
  • Added GW protein: NSs
    9 years, 9 months ago
  • Wsearch on-line implementation
    9 years, 9 months ago
  • Whub - initial release
    9 years, 9 months ago